A recent study suggests that people who discontinue popular GLP-1 drugs like semaglutide or tirzepatide can put back on reduced body mass far faster than those who stop traditional lifestyle plans.
Published data in a leading health publication points out that while obese people can lose about a fifth of their total mass while using the jabs, the weight is regained at an estimated rate of 0.8 kg per month after stopping.
"Users using these treatments must be informed of the potential of rapid rebound weight gain when the therapy ends," cautioned lead investigator Dr. Susan Jebb.
Such speed of regain suggests a reversion to pre-treatment weight in about a year and a half.
Analyzing Treatments
The analysis, which reviewed 37 of studies involving thousands of patients, contrasted the outcomes of the injectable medications with conventional dieting.
Researchers emphasize that individuals who shed pounds through diet and exercise generally have a less rapid weight regain—perhaps 0.1 kg a month—post-intervention.
Explaining the Rapid Regain
Doctors suggest the mode of action of the drugs is key to understanding the heightened regain.
These medications mimic a natural hormone called GLP-1, which helps regulate feelings of fullness.
"Artificially providing the hormone levels several times higher than the body's typical production could lead to the body to produce less of its endogenous hormone, and may also diminish sensitivity to its actions," said Dr. Adam Collins, a nutrition expert.
"Discontinuation of this medication leads to appetite is no longer kept in check, making overeating much more probable."
A Chronic Issue?
Health authorities recommend the jabs for people with obesity-related medical conditions, accompanied by prescribed diet and exercise modifications.
Professionals say that, considering the high risk of relapse, the treatment might need to be life-long.
This opinion is reinforced by drug manufacturers, who note that the results "underscore the chronic character of excess weight," comparing it to managing diseases like diabetes.
User Accounts
Individuals who have discontinued the jabs describe a sudden return of hunger.
"I experienced something that goes on and you become ravenous," recalled an individual.
This difficulty is exacerbated if individuals have not adopted lasting dietary or behavioural modifications during therapy.
Significant Interest
Recent estimates show that a significant number of adults in the UK have tried weight-loss jabs in the past year, with demand remaining high.
- Adoption is greater among females compared to men.
- The 40s and 50s demographic shows the highest usage rates.
- A large proportion access the drugs through private prescriptions rather than the NHS.
Ultimately, experts emphasize that while the jabs are powerful agents for weight loss, they are not a standalone cure and maintained weight loss hinges on combined lifestyle changes.
